Man Citys draw against Tottenham and Liverpools comeback against Fulham has put some extra weight on the upcoming schedule.
The Reds know they have it in them to compete for the title but it has been relegation-threatened sides against which Klopps team have struggled.
Heres how Liverpool could line up for their match against Sheffield United.
Heres what Klopp revealed in his press conference:
With Liverpool in the middle of a run featuring eight matches in 24 days, rotation from Klopp is inevitable and necessary, most would argue.
Jotas absence in attack makes things more straight forward in attack, as it means the impressive Cody Gakpo will almost certainly be awarded a start on Wednesday or Saturday.
Matips injury also makes things fairly simple in defence, with Ibrahima Konate to start alongside Virgil van Dijk, meaning Jarell Quansah is first reserve.
Heres what we expect to happen.
This is how Liverpool would line up:
Kelleher; Alexander-Arnold, Konate, Van Dijk, Tsimikas; Endo, Szoboszlai, Jones; Salah, Nunez, Gakpo
Alternatively, we could see Alexis Mac Allister start despite being taken off after 65 minutes against Fulham due to fatigue.
As it is an away match, we could also see Gomez reprise his role at left-back, like against Luton, with Diaz retaining his left-wing spot.
Darwin Nunez is dropped to the bench in this scenario.
Heres how this alternate team would look:
Kelleher; Alexander-Arnold, Konate, Van Dijk, Gomez; Mac Allister, Szoboszlai, Jones; Salah, Gakpo, Diaz
Having played Europa League football this season, Liverpool should be well-versed in going out to get a result with different players on the pitch.
With that in mind, Sheffield United shouldnt pose a problem, especially given there should be fewer changes for this than in Europe.
However, with Chris Wilder returning as manager under the floodlights, we know three points arent guaranteed.