After being held to a goalless draw by Crystal Palace, Liverpool are in need of a victory on Wednesday evening to keep their top four hopes alive.
Alisson starts in goal and will be hoping for a fourth consecutive Premier League clean sheet.
Theres two changes in the back four, with Trent Alexander-Arnold at right-back, Konate partnering Virgil van Dijk at centre-back, and Kostas Tsimikas at left-back.
Klopp has changed the entire midfield trio, with Fabinho starting behind Harvey Elliott and Stefan Bajcetic.
Liverpools sixth changes come in attack, with Nunez coming in alongside Mohamed Salah and Diogo Jota.
Joel Matip, Andy Robertson, Jordan Henderson, James Milner, Naby Keita and Cody Gakpo are the six players to drop out.
Keita is not included on the bench, with Curtis Jones also left out of the squad.
Liverpool: Alisson; Alexander-Arnold, Konate, Van Dijk, Tsimikas; Fabinho, Elliott, Bajcetic; Salah, Jota, Nunez
Substitutes: Kelleher, Matip, Robertson, Milner, Henderson, Oxlade-Chamberlain, Carvalho, Gakpo, Firmino
Wolves: Sa; Semedo, Dawson, Kilman, Bueno; Lemina, Moutinho, Neves, Nunes; Sarabia, Jimenez
Substitutes: Bentley, Ait-Nouri, Collins, Jonny, Joao Gomes, Traore, Neto, Podence, Costa