Should Salah score he will become the Reds leading scorer away from home in the Premier League era.
He is currently on 55, alongside Michael Owen.
Salah played his first game in English football against Newcastle a substitute in Chelseas home league win in February 2014.
He has six goals in 11 appearances for Liverpool against the Magpies.
Against Eddie Howe teams, Salah has scored nine goals in nine games.
Tonight Liverpool could keep back-to-back clean sheets in the league for only the second time this season.
They could also keep three in a row at St James Park in the league for the first time in their history.
Liverpool have won 32 and lost 11 of their 55 Premier League meetings with Newcastle, with 10 of those 11 defeats coming at St James Park.
In 27 Premier League games at St James Park, the Reds have won 10, drawn seven and lost 10.
However, they are unbeaten in their last five trips to Newcastle: three wins, two draws.
Liverpool have scored 44 Premier League goals at Newcastle. Only at Tottenham have they netted more (45).
Roberto Firminos next appearance will be his 350th for Liverpool in all competitions.
Andy Robertsons next league appearance will be the 350th of his club career with Queens Park, Dundee United, Hull City and Liverpool.
Newcastle are unbeaten in 17 league games the longest such streak in the top five European leagues.
This is the Magpies longest unbeaten top-flight run and if they avoid defeat in this game they will set a new club record, eclipsing the 17 set in the second tier from February to May 2010.
They have drawn 11 times in the league, the most of any team in the top division.
They are unbeaten at home in the league in 12 games. The last team to defeat them on Tyneside wasLiverpool, back in April.
Bruno Guimaraes serves the final game of his three-match ban tonight, as a result of his red card against Southampton in the Carabao Cup.
With Guimaraes this season Newcastle have won 10 and drawn seven of 17 league games.
Without him they have played five and are yet to win, with four draws and a defeat.
Howe has won one of 16 clashes with Liverpool as a manager, with a draw and 14 defeats.
His teams have conceded 39 times in that sequence, with 33 of those coming in the 13 league encounters.
Anthony Taylor took charge of the Club World Cup final won by Real Madrid last weekend and refereed Man Citys win at Arsenal in midweek.
He has not refereed Newcastle for more than a year.
Newcastle: Almiron 10, Wilson 7, Guimaraes 4, Joelinton 4, Isak 3, S.Longstaff 3, Wood 3, Willock 2, own goals 2, Burn 1, Lascelles 1, Murphy 1, Saint-Maximin 1, Schar 1, Trippier 1
Liverpool: Salah 18, Nunez 10, Firmino 9, Elliott 5, Diaz 4, own goals 4, Alexander-Arnold 3, Carvalho 3, Van Dijk 2, Bajcetic 1, Gakpo 1, Matip 1, Oxlade-Chamberlain 1
* Stats courtesy of LFC statistician Ged Rea (@ged0407).
