Here are three key points from Klopps post-match press conference
After 120 minutes and penalties at the weekend, there was no other option than to make almost wholesale changes for the trip to St Marys.
Alisson and Ibrahima Konate were the only players to keep their places, with goalscorer Takumi Minamino joining the likes of Harvey Elliott, Joe Gomez and Curtis Jones in being handed a rare start.
Im so happy about the performance, it was a bit touching, to be honest, Klopp said.
These boys, like having Ferraris in the garage. Harvey, Curtis, Takumi Minamino, Oxlade didnt even play and hes in outstanding shape.
Its really tough for the boys but whatever happens this year happened because of this group. Its exceptional.
Tonight they showed that.
Following Nathan Redmonds early goal, Liverpool were dealt another blow in the first half with Gomez forced off with a worrying injury.
The right-back did not return after the break, with Jordan Henderson taking his place, but Klopp is hopeful we are lucky in avoiding a serious problem.
Joey himself has pain but not too much, but it was really like a shock to the system, he explained.
He was sitting in the dressing room, when I spoke to him he was in a good mood.
I think we were probably lucky.
Unfortunately, Gomez was then spotted leaving St Marys on crutches, suggesting it could be a bigger issue.
With victory at Southampton, the Reds reduced the gap at the top of the table to just one point ahead of the final day of the Premier League.
Man City host Aston Villa and Liverpool take on Wolves at Anfield, with a win imperative while fingers are crossed that Steven Gerrards side can take points at the Etihad.
We have to first win our game, its difficult enough, Klopp said.
Imagine we went there with one ear in Manchester and Jimenez headed in the ball.
So many things happened in this second half of the season. If we became champions it would be deserved as well.
Asked if he would speak to Gerrard ahead of the curtain-closer, he declined, saying: We all know Villa wants to win because Villa wants to win.