A new week presents new challenges and the prospect of another trophy for the Reds, but the latter is on the backburner for now as the Premier League takes centre stage.
The draw against Tottenham last time out was far from ideal as Man City then responded with a 5-0 thumping of Newcastle to extend their lead at the top to three points.
It means nothing but a win will do at Villa Park as the Reds look to at least take the title race to the final day.
But with the embarrassment of riches Liverpool possesses, Klopp is not short on options to get the job done the question is how many changes is he willing to make?
There are two ways Klopp can go about his selection with this fixture, and an eye on the FA Cup final on Saturday could more than play its part in the managers final decision.
In this instance, we could see just three changes one across each line as there are still four days to rest, recover and prepare for Chelsea at Wembley.
Joel Matips return feels inevitable, while Naby Keita will be eager to slot back into the midfield:
This would have the Reds lining up as follows:
Alisson; Alexander-Arnold, Matip, Van Dijk, Robertson; Fabinho, Henderson, Keita; Salah, Jota, Mane
On the other hand, there could even be up to as many as seven changes and it would unlikely come as a surprise to supporters should that be the case.
It would not be conceding defeat in the league as the team would certainly still remain incredibly strong, but it allows for a valuable rest for a handful of Reds expected to start at Wembley:
Those changes see the Reds shape up like this:
Alisson; Gomez, Matip, Van Dijk, Tsimikas; Henderson, Keita, Jones; Salah, Jota, Firmino
It could very well be that Klopp looks to settle somewhere in the middle so as to not unsettle the balance and rhythm of the team, but Liverpool certainly has the depth to make mass changes.
The Reds know more than most not to underestimate Aston Villa but Klopps side, whichever he picks, ought to be more than capable of getting the required result before focusing on a Wembley final.