After the success of the Liverpool Legends exhibition friendly against Barcelona at Anfield, the ex-Reds are on the road this time around.
The 2-1 loss to their Spanish counterparts in March saw a sell-out crowd help raise 1 million for the LFC Foundation and various other causes, including Forever Reds and the Owen McVeigh Foundation.
Some of those who featured that day will be making the trip to Manchester this afternoon, but the Liverpool side to play Man United also includes a number of new faces.
Jermaine Pennant, who made 81 appearances for the club in the late 2000s including a man-of-the-match display in the 2007 Champions League final, is among those in the squad.
Speaking to This Is Anfield ahead of the game, Pennant relished another instalment in a massive rivalry.
Its always a tough time playing Man United well it was and Im sure its going to be tougher this time around now, the 39-year-old winger said.
I enjoy playing against them, especially being a Liverpool boy, a supporter, an ex-player.
The rivalry is always massive, it doesnt matter if its competitive, Premier League, it doesnt matter what kind of level it is, its always competitive and its going to be a good atmosphere for sure.
It will be Pennants third time representing the Liverpool Legends, having last worn the shirt in action during a 3-2 win over Rangers in Glasgow in 2019.
Its going to feel great. Some old legends, some past team-mates, players I played against as well probably, he continued.
Its always amazing to be involved with Liverpool.
Whether its on the pitch, off the pitch, LFCTV, its always a pleasure and I enjoy every moment of it.
The likes of Jamie Carragher, Dirk Kuyt and Maxi Rodriguez are also involved this afternoon, with Pennant successful in his pitch to join them.
Im close with Jason McAteer, and Im always saying is there any danger of getting me involved?, he explained.
I spoke to Aldridge as well, because we do some tours together as well, and they just put me in touch and obviously Sir Kenny and Ian Rush picked the team and I made the cut this year!
These occasions are, of course, about raising funds for the club charities, but for the players it is an opportunity to play in front of the fans again and catch up with old friends.
I want to see Mark Gonzalez, Pennant told This Is Anfield.
He had something wrong with his heart and wasnt well at one stage, so it will be nice to see him back, fit and well and playing football.
Dirk Kuyts going to be there as well from my era, so therell be some faces from my team who itll be good to see for sure.