Both City and Dortmund got off to winning starts in the European competition last week, with the Blues beating Sevilla 4-0, as the Black and Yellows recorded a 3-0 victory over FC Copenhagen.
When the groups were drawn, this fixture was always the one to watch, as both teams fight to finish top and hopefully find themselves avoiding a potentially tricky tie in the next round. These two sides will be familiar with one another, as their last meeting came just over a year ago.
City and Dortmund were drawn against each other in the quarter finals of the competition during the 2020/21 season that saw Pep Guardiola's side agonisingly lose to Chelsea in the final. Erling Haaland has of course switched sides, yet the Norwegian did not get on the scoresheet in either leg, despite starting both matches.
The 22-year-old will be raring to go as he comes up against his old team, eager to show them exactly why he made the move to the Premier League champions. Having already scored two Champions League goals for the Blues against Sevilla, many fans think that Haaland might finally be the missing piece to the puzzle in their quest to get their hands on the elusive European trophy.
Here's all you need to know ahead of Wednesday night's game.
You can watch the match on BT Sport 2 and BT Sport Ultimate. Coverage of the game will begin at 7pm, with the game kicking off at 8pm on Wednesday, September 14. BT Sport customers will be able to live stream the match on BT Sport's website.
The Manchester Evening News will bring you live updates from the Etihad Stadium in our live matchday blog.
Man City – 2/11
Draw – 13/2