Mauricio Pochettinos side did not play convincingly in their 4-1 win over nine-man Tottenham on Monday but the result means they have now lost just one of their past seven matches. City also go into the weekends game on the back of a win.
Their triumph over Young Boys in midweek secured their place in the Champions League knockouts with two matchdays to spare. A number of players were rested during the fixture, meaning they could well get the nod in the clubs final game before the international break.
Ederson will undoubtedly start and will be eager to build on his clean sheets tally. He has amassed just five in his 15 games so far, a ratio both he and Pep Guardiola will want to improve given the goalkeepers traditionally high standards.
Manuel Akanji was due to start against Young Boys but pulled out during the warm-up after feeling discomfort. And so, despite not featuring at all on Tuesday, he might be left out again having not got up to full speed in training this week.
Nathan Ake could fill the void left by the absent John Stones. With the break coming up, Guardiola has no reason to rest and rotate at full-back so preferred picks Kyle Walker and Josko Gvardiol could get the nod.
Rodri stayed on the bench in midweek, meaning Chelsea will be facing a fully-energised Spaniard. Bernardo Silva has been in imperious form of late and is keeping out summer signings Mateo Kovacic and Matheus Nunes with his deeper lying role.
Meanwhile, Julian Alvarez will surely play in behind the striker again, having been praised by his manager for his central abilities this week.
Phil Foden has shown his versatility again this season, producing the goods on either flank, with Jeremy Doku doing the same in some style. His four assists and goal against Bournemouth combined with his bench appearance on Tuesday may mean he starts against Chelsea.