Erik ten Hag has said he is actually pleased with the clubs start to the season amid the plethora of setbacks, with more being added to the physio chart over the past week. The latest to suffer injury is Christian Eriksen.
The Dane is out for a month with a knee issue while Rasmus Hojlund is also set for a spell on the sidelines with a strain. Lisandro Martinez and Casemiro, meanwhile, are out for the rest of the year. United could make up a strong XI out of the players who have been injured since the start of pre-season.
Perhaps the weakest position in the XI with Andre Onana and Altay Bayindir injury-free so far. Heaton missed the start of the season with a calf injury picked up in the days before the opening match against Wolves.
Wan-Bissaka was ruled out for more than a month with a hamstring injury and made his comeback in the League Cup defeat to Newcastle. He was too ill to feature against Luton.
The defender missed three games – defeats to Arsenal, Bayern Munich and Brighton – with an unspecified complaint and sat out the win over Brentford with a minor issue. He has since struggled to get back into the side amid the form of Harry Maguire, albeit is still considered the better quality player by many.
Martinez is out until 2024 due to a recurrence of a metatarsal injury first picked up in April. He required another round of surgery and faces a long road to recovery with the club keen to get it right.
Many supporters have said Shaw has been the player United has missed most. His muscular injury has meant he has not played since August, although he could be back by the end of November or early December.
The Brazilian picked up a hamstring issue in the League Cup loss to Newcastle having just come back from a foot complaint sustained while on Brazil duty. He is not expected back until the new year.
The Moroccan missed the first few United games after his arrival when he sustained an unspecified injury. He eventually made his debut against Burnley in September.
Mainoo is perhaps the player supporters are excited to see return the most. He is back in the matchday squad after recovering from a pre-season ankle injury sustained against Real Madrid having featured a handful of times for the academy.
Supporters are also eager to see Amad return to the fold. His knee injury against Arsenal in pre-season means he is yet to enjoy a minute of action this campaign but the attacker seems to be close to a return.