Christian Eriksen is set to spend a month on the sidelines and Rasmus Hojlund should be back by the end of November, after the Danish duo both suffered setbacks in the weekend win over Luton and subsequently withdrew from international duty.
Eriksen could miss as many as seven matches after his latest injury setback but there is hope Hojlund might only miss one, if any at all.
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The 20-year-old striker has only suffered a &aposmuscle strain&apos as opposed to a serious injury and there is hope he will be back before the end of the month, as long as there are no further setbacks.
If he were to miss one match, then it would likely be their next match, away to Everton on November 26. Even if he is fully fit, there is an argument to rest him from the start to ensure he is as fresh as possible for a must-win trip to face Galatasaray three days later.
United will already be without the suspended Marcus Rashford for that trip to Istanbul and the prospect of also being without Hojlund, the top scorer in the Champions League, doesn&apost bear thinking about.
It once again highlights United&aposs reliance on a raw striker who has yet to net a goal in the Premier League and the huge amount of pressure that has been dumped onto his shoulders due to wider recruitment issues.
Hojlund has shown enough so far to suggest he could become a huge success in a United shirt, though his latest injury scare raises fresh questions about his workload and United&aposs handling of a player who was already injured when he signed.
Part of the problem has been United&aposs lack of suitable back-up in attack. It is an issue that could rear its ugly head once again in the coming weeks.
Even if he is fit for the away trip to Everton, Hojlund will need to be managed carefully and can&apost be expected to play every minute of every game in the build-up to the frantic festive period.
It leaves Erik ten Hag with three alternative options up front: Rashford, Anthony Martial, or a false nine.
Rashford is well-documented to prefer playing on the left wing and even when he has enjoyed success as a striker, it has tended to be when he has cut inside from his favoured flank anyway.
The 26-year-old struggles with his back to play and having limited space to run at his opponents, and his tally of just one goal this term also makes it an illogical option.
With the forward now low on confidence, he has not made the right decisions in the final third and has stopped making the menacing runs that brought him so much joy last season.
Ten Hag has insisted that it would only take one match for Rashford to regain that self-belief, though the longer it goes on, the less likely it becomes.
United&aposs other obvious option would be to give Anthony Martial another chance in the forward line, but there is little evidence to suggest it would bring any positive results.
The Frenchman is clearly out-of-favour and down in the pecking order under Ten Hag and does not deserve another opportunity based on merit.
Martial&aposs only goal this season was a really well-taken one against Crystal Palace in the Carabao Cup, but when the pressure has been on, he has been on the bench. Even when he has been introduced, he has struggled to make any impression.
With the 27-year-old out-of-contract at the end of the season, it would be another damning reflection of United&aposs planning if they were left relying upon him again, not to mention if they ended up offering him another deal on the back of it.
United&aposs wildcard option would be to utilise a false nine, something they have used a few times but largely experienced little joy with under Ten Hag.
In his first Premier League match in charge of the club, the Dutchman deployed Christian Eriksen in the role, with little joy as they lost at home to Brighton. Bruno Fernandes also has experience playing there, doing so under Ralf Rangnick when they looked to use an extra midfielder in a defeat to Manchester City last year.
Most notably, Jadon Sancho looked rather promising in the role during pre-season but he is no longer considered an option by the manager and looks certain to leave the club in January.