The Dutchman's squad are under pressure to come away with all three points following their Group E openening match loss to Real Sociedad last week. United fell to a disappointing 1-0 defeat after Brais Mendez tucked home from the penalty spot as the Spanish outfit were awarded a controversial penalty for handball on Lisandro Martinez after the ball appeared to ricochet off of his leg before hitting his outstretched arm.
The club have confirmed the midweek tie will go ahead following postponements in the Premier League and Football League following the death of Queen Elizabeth II last week. But they will travel to Moldova without a full contingent, with several stars set to miss out through injury.
With that in mind, Manchester Evening News has taken a look at the players currently on the United treatment table.
Anthony Martial will have been left frustrated by his recent injury woes.
The French forward had looked to be in impressive form for Erik ten Hag's side in pre-season before injury curtailed his bid to cement a spot in the Dutchman's starting XI. Martial has suffered a problem with his Achilles after playing just 45 minutes of league football for United this season.
Ahead of the tie against Sociedad, Ten Hag said: “Yes, he is still out. He is progressing but he is not ready to get back into team training or in a game.”
It suggests Martial could have a little while yet before he is once again available for selection.
Donny van de Beek will have also been hoping to impress new boss Ten Hag, having also struggled to get into United's starting XI on a regular basis under Ole Gunnar Solskjaer before being farmed out to Everton on loan by Ralf Rangnick.
But the Dutch midfielder was left out of the squad against Arsenal due to a knock and is yet to regain his place. While he missed the Europa League opener against Real Sociedad, it is hoped that Van de Beek will be okay for Thursday night's visit to take on Sheriff.
England left-back Luke Shaw had been expected to get a chance to prove himself against Real Sociedad last week but failed to get on the pitch.
It has now been revealed that defender is struggling with a foot injury, with United manager Erik ten Hag saying he has a “small complaint”. The injury could rule him out of the tie against Sheriff and even affect his chances of an international call-up when Gareth Southgate announces his World Cup squad on Friday.
Facundo Pellistri has been ruled out with injury ever since twisting his ankle in pre-season.
Speaking last month, Ten Hag issued an update on his status, saying: “The prognosis is that he will not return before September.”
Pellistri has been called-up for international duty with Uruguay later this month, suggesting his national team bosses have some intel that he could be set to return before they next play.
Uruguay are due to take on Iran on Friday, September 23 before playing Canada on Tuesday, September 27.
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