Erik ten Hag&aposs side picked up their first win of the European campaign in the reverse fixture and need another three points tonight if they are to keep their qualification hopes alive.
Marcus Rashford should be available again after missing the weekend trip to Fulham, while Victor Lindelof is also available again after a recent illness.
TEAM NEWS: How United should line up tonight
Here are the main talking points ahead of the match:
Defensive duo
Erik ten Hag&aposs most important decision tonight could come in central defence as he looks for the ideal partner for Harry Maguire.
Raphael Varane is the obvious choice on paper, but Jonny Evans has been selected over him in recent weeks, with the Northern Ireland international starting their last three league wins.
United&aposs problem is that Evans can&apost play two games a week, while there are long-term reservations over Varane&aposs fitness levels and his concerning injury record.
After such a poor start to the season, &aposconsistency&apos and &aposmomentum&apos are the two buzzwords of choice going forward, both of which would be helped by having a settled centre-back partnership.
Maguire thoroughly deserves his place back in the lineup, but there is still some debate over who should partner him in the long run.
It&aposs not alright on the right
Antony&aposs struggles continued at the weekend, but that doesn&apost mean he will be dropped tonight. The Brazilian is in the running to be considered the club&aposs worst-ever signing and it is in Ten Hag&aposs best interest to try and make his man work on the right wing.
There is always a temptation to try and play someone into form, knowing that one goal or moment of magic could kickstart their career, but there have already been a number of false dawns with Antony.
United&aposs dilemma was that they never had a viable alternative option, though after a game-changing cameo against Fulham, there is an argument for Facundo Pellistri to start tonight.
He is the more in-form option, but he has never shone from the start of a competitive match for the club and has been far more effective from the bench.
Antony doesn&apost deserve to start, yet he might.
Turned a corner?
United thought they had turned a corner with their dramatic win over Brentford last month. Instead, they just ended up going full circle.
The gritty weekend win over Fulham was once again viewed as a possible turning point in the season, though it will count for little if they drop points in either match this week.
Consistency is the key for a United side looking to build momentum under Ten Hag and once again, tonight will be all about winning by any means necessary.
There is certainly huge room for improvement with United&aposs performance as of late, but as long as they are winning, that is all that matters for now.
Rashford&aposs role
Erik ten Hag insists Marcus Rashford would have started had he been fit for the trip to Fulham, though some cynics questioned the timing of his injury, a day after he was criticised by the manager for partying after the derby defeat to Man City.
The fitness issue has to be taken at face value and Rashford will be expected to start tonight. He will also be expected to put in a much better performance than any so far this season.
Rashford has only netted one goal in his last 14 club appearances and his record in the Champions League hasn&apost been much better either. The England international hasnt scored in any of his last seven appearances in the competition, with his last strike coming in October 2021 v Atalanta.
If he plays and fails to find the net tonight, it will be his longest run of appearances without scoring in the competition (also a run of seven). Score and win and it really will be party time.
Paying the penalty
There has been a common theme across the European campaign so far. No, not that United have been poor in all their matches, though that is certainly valid.
