Manchester United predicted line-up vs Bayern Munich as Sergio Reguilon and Rasmus Hojlund start – George Smith

United, who last faced the German heavyweights in a competitive fixture back in 2014, will be looking to bounce back from Saturday&aposs 3-1 defeat at home to Brighton & Hove Albion. Goals either side of half-time from Danny Welbeck, Pascal Gross and Joao Pedro condemned the Reds to their second successive defeat.

As a result of that latest setback, United have lost three of their opening five matches this season, meaning they take far from the ideal run of form into the tussle with Bayern. Furthermore, the Reds&apos squad is currently plagued by injury issues, so much so that four goalkeepers have been included in the 21-man squad that has flown to Germany.

Despite featuring in Tuesday morning&aposs open training session at Carrington, Raphael Varane and Mason Mount have both been ruled out once again, as has Harry Maguire, who is the latest addition to the ever-growing injury list. It means manager Erik ten Hag is now working with a much smaller squad than he would prefer.

However, despite all of the ongoing issues, summer signing Andre Onana is expected to continue in goal and make his first European appearance in United colours. The Cameroonian, who has kept just one clean sheet so far this season, helped Inter Milan reach the final of the Champions League last season.

Ahead of the 27-year-old, Ten Hag is likely to name the exact same back-four that started the defeat to Brighton, meaning Diogo Dalot and Sergio Reguilon will occupy the full-back berths and Lisandro Martinez and Victor Lindelof will start at centre-back. The likes of Aaron Wan-Bissaka, Luke Shaw, Tyrell Malacia, Varane and Maguire are all unavailable.

Wan-Bissaka, who was a surprise omission from the starting line-up at the weekend, faces a spell on the sidelines with a hamstring injury. It remains to be seen how long he could be unavailable for.

In midfield, Ten Hag could revert back to a more familiar three-man system, deploying Christian Eriksen and Scott McTominay alongside Casemiro in the engine room. United operated with a four-man midfield diamond against Brighton, a tactic that failed to pay off.

Should either McTominay or Eriksen start in the more advanced midfield berth, it is likely that Bruno Fernandes will be pushed out wide and start on the right flank, just as he often did against the so-called bigger teams last season. Facundo Pellistri remains in the hunt for a start on the right wing, but Ten Hag may not be comfortable throwing the youngster in from the start.