United, who beat the Londoners 4-1 in their most recent meeting back in May, saw their three-game winning run in the league come to an end on Saturday, losing 1-0 to Newcastle United at St James&apos Park. Anthony Gordon netted a second half winner to secure all three points for the Magpies.
The manner of United&aposs showing on Tyneside, coupled with their 3-3 draw with Galatasaray in the Champions League 72 hours earlier, has meant pressure is increasing on manager Erik ten Hag. The Reds are currently seventh in the Premier League table.
The Dutchman, who guided United to four points from a possible six against Chelsea last season, is poised to pick from the same crop of players that were beaten by Newcastle, though Mason Mount could return to the matchday squad after a recent injury problem.
Ten Hag is expected to stick with Andre Onana in goal. The former Inter Milan shot-stopper has been an ever-present figure in all competitions so far this season. Aaron Wan-Bissaka could continue at right-back and is likely to have Harry Maguire to his left, with the England ace deservedly one of the first names on the teamsheet on current form.
Ten Hag may again decide to deploy Luke Shaw at centre-back but Diogo Dalot could make way for Sergio Reguilon with the Spaniard capable of providing a left-footed presence on that side of the back-four.
In midfield, Kobbie Mainoo&aposs could get a third league start in succession at the base of the engine room. Scott McTominay and Bruno Fernandes are likely to join him while Sofyan Amrabat will be targeting a recall having not started a league game since the derby day defeat to Manchester City on October 29.
In attack, Ten Hag may hand a recall to Rasmus Hojlund and deploy him through the middle at the expense of Anthony Martial, who experienced a difficult night at St James&apos. Antony, despite his struggles this season, should have started against Newcastle after a spirited performance against Galatasaray and he could take the place of Marcus Rashford.
Alejandro Garnacho, who has been United&aposs best attacker in recent weeks, should be a guaranteed starter on the left. He will be looking to add to the goals he recently plundered against Everton and Galatasaray.
United predicted line-up: Onana; Wan-Bissaka, Maguire, Shaw, Reguilon; Mainoo, McTominay, Fernandes; Antony, Hojlund, Garnacho.