Wan-Bissaka was named on the bench for Brighton&aposs visit to Old Trafford on Saturday afternoon because he&aposd been unwell in the week leading up to the game, but he was brought off the bench in the 85th minute.
The right-back sustained an injury in the closing stages and he&aposs now facing a spell on the sidelines for several weeks.
Wan-Bissaka is now unavailable for Wednesday&aposs Champions League match against Bayern Munich and the club has confirmed a further assessment is required to determine the exact length he&aposs expected to be sidelined for.
Prior to the weekend, Wan-Bissaka had started every league game so far this season after winning back his starting role last term.
Erik ten Hag is currently contending with an injury crisis in his squad and Wan-Bissaka joins teammates like Tom Heaton, Raphael Varane, Mason Mount, Soyfan Amrabat and Kobbie Mainoo who are also currently dealing with injuries.
Ten Hag, speaking after the Brighton defeat, indicated one unnamed player would be in contention to make the travelling squad.