City are the favourites ahead of the tie on the south coast at 2/9 with Betfred while the Saints are longshots at 11/1 and a draw is 11/2. Guardiola has won the trophy four times in succession from 2018 to 2021 but were knocked out in the fourth round last season to West Ham United on penalties.
The visitors have beaten heavyweights Chelsea and Liverpool on their way to the quarter-finals so far in this season&aposs competition.
For Southampton, they will be looking to produce a shock and get themselves through to the semi-finals for this first time since [enter year]. They have seen off Cambridge United, Sheffield Wednesday and Lincoln City before setting up the home tie against Pep Guardiola&aposs side.
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Julian Alvarez to score anytime – 5/6
Man City to win to nil – Evens
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