United remain the only side to have beaten Arsenal in the league and their 3-1 victory on September 4 came with Casemiro on the bench.
Ten Hag could recall Scott McTominay or Fred at the Emirates Stadium, where Newcastle are the sole side to have avoided defeat in the league so far this season.
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Mikel Arteta has earned plaudits for the progress he has overseen at Arsenal, who have emerged as unlikely title challengers 19 years on from their last triumph.
“It is obvious they are in a really good run and I think they deserve the position where they are now,” Ten Hag said. “It is a really good structure and how they play is with a really good mentality and winning attitude in the team. Thats why they are top of the list. They are in a great run but it is up to us to beat that run. We will do everything to do that.
“At the moment we played them when we could already see that the manager and the coaching staff was for a long time already working on the team and you see a really good structure in the team.
“I think they have even improved during the first half of the season and there is a really good spirit in the team as well, so we know what to do.
“We have to be really good and need a really good performance but if we do we have a good chance also to get out of that performance a good result.